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KMID : 0880520160520010012
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Chonnam Medical Journal
2016 Volume.52 No. 1 p.12 ~ p.17
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Signaling Pathways in Osteoclast Differentiation
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Kim Jung-Ha
Kim Nack-Sung
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Abstract
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Osteoclasts are multinucleated cells of hematopoietic origin that are responsible for the degradation of old bone matrix. Osteoclast differentiation and activity are controlled by two essential cytokines, macrophage colony-stimulating factor (M-CSF) and the receptor activator of nuclear factor-κB ligand (RANKL). M-CSF and RANKL bind to their respective receptors c-Fms and RANK to stimulate osteoclast differentiation through regulation of delicate signaling systems. Here, we summarize the critical or essential signaling pathways for osteoclast differentiation including M-CSF-c-Fms signaling, RANKL-RANK signaling, and costimulatory signaling for RANK.
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KEYWORD
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Bone and bones, Macrophage colony-stimulating factor, RANK ligand, Osteoclasts, Signal transduction
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